(HE-011) Comparative Effectiveness of Collagen/oxidized Regenerated Cellulose/silver-orc Dressing* with Cellular Tissue Product versus Cellular Tissue Product Alone in Wound Care

Leah Griffin, MS – Solventum

Introduction: This study was designed to examine the difference in outcomes between wounds treated with collagen/oxidized regenerated cellulose/silver-orc dressing (COSO)* and a cellular tissue product (CTP) and wounds treated with a CTP without COSO.

Methods: Using U.S. Wound Registry data, 1,674 wounds treated with OCSO+CTP were identified. Propensity score matching within each wound type was used to create a cohort of 1,674 control wounds that used CTP alone. Outcomes evaluated included the healing status and change in wound size. Chi-square and t-tests were used to evaluate differences between the two cohorts.

Results: After matching, the two cohorts were balanced on most patient and wound demographics. Those variables that were not fully balanced (wound age, smoking, and vascular disease) indicated that the wounds treated with COSO+CTP were older and on patients who had a higher percentage of risk factors. Significantly more wounds were healed when treated with COSO+CTP compared to CTP alone (49.0% versus 43.8%; p< 0.0001) with an odds ratio of 1.24 (95% Confidence Interval: 1.09, 1.43). When healed wounds were combined with wounds that improved, there continued to be a significant difference in favor of the COSO+CTP cohort (83.3% versus 80.1%; p=0.0158). There were no differences in the change in wound size.

Discussion: Despite the COSO+CTP treatment group having a higher percentage of risk factors, this group had much better outcomes than the CTP group. Using COSO+CTP for a wide range of wounds may help to improve patient outcomes.