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Case Series/Study

(CS-032) Regenerative and Antibacterial Properties of Lyophilized Piscis Dermis for the Treatment of Challenging Surgical Wounds

Friday, May 2, 2025

7:45 PM – 8:45 PM East Coast USA Time

Talia Selembo, BS; Sammy Shihadeh, BA

Introduction:
Despite repeated excisional debridements and aggressive wound care burn wounds, traumatic injuries, surgical wounds from abdominal catastrophes and necrotizing soft tissue infections (NSTI) may remain heavily colonized. Most skin-substitutes are highly sensitive to bacterial colonization and infection. Decellularized and lyophilized fish dermis (DLFD) have been shown in-vitro to possess effects decreasing bacterial migration and proliferation acting as a bacterial barrier. Omega-3 contribute to these attributed effects. DLFD may serve with bacterial protection and enhance optimal wound regeneration in preparation for grafting.

Methods:
Multiple patients with numerous comorbidities sustaining full-thickness skin defects and complicated wounds with at least heavy bacterial colonization were included. These patients had sustained traumatic and surgical wounds from abdominal sepsis and NSTI, and they underwent prior debridements and local wound care. Application of DLFD and negative pressure wound therapy was then performed. Subsequently, they underwent resurfacing with a split-thickness skin graft (STSG).

Results:
Despite bacterial colonized environment complete Xenograft incorporation and wound enhancement for grafting was noted within 5 to 14-days. Graft integration and optimal granulation tissue was evidenced in >95% surface area as early as 5-days after product application. No graft loss occurred. Subsequent, STSG revealed nearly 100% graft-take and epithelization within 2-weeks.

Discussion:
DLFD provide excellent wound coverage of colonized wounds, act as bacterial barrier, and enhances formation of optimal wound bed for skin-grafting. Even though these properties have been observed, we do not advocate using any skin substitute on an infected field. Adequate wound bed preparation is paramount for the success of our patients.