(PI-017) Chronic Wound Healing: The Essential Role of Copper-based Dressings in Innovative Care

Introduction: Effective treatment options are crucial for chronic wound healing, and copper-based dressings* have emerged as a novel solution. Copper's unique properties support wound healing and serve as a good alternative to traditional antimicrobial agents like silver and iodine which have been utilized for years. As an essential trace mineral, copper is critical for the proper functioning of body tissues, making copper-infused dressings a more natural choice with fewer adverse effects.

Methods: We introduced Copper alginate dressings* to chronic non-healing wounds in the wound care setting. Focusing on wounds stalled in the inflammatory phase or showing clinical signs of biofilm formation and infection.

Results: By implementing Copper dressings* significant advantages over silver were found. Copper penetrates bacterial cell membranes electrostatically, preventing bacterial replication. They reduced inflammation by lowering pro-inflammatory cytokines and growth factors while promoting pro-angiogenic factors for new blood vessel formation. Additionally, they enhanced dermal fibroblast activity and acted as a cofactor for lysyl oxidase, linking collagen and elastin in the extracellular matrix. Copper also exhibited broad-spectrum biocidal properties, with rare occurrences of tolerant bacteria. Patients who utilized this dressing in our clinic showed decreased inflammation, degradation of biofilm, decreased infection rates, and improved weekly wound measurements at clinic visits.

Discussion: Incorporating copper dressings into the care of chronic wounds can make a remarkable difference. These innovative dressings offer unique benefits that can enhance healing and promote better outcomes. This new approach targets chronic inflammation, disrupts biofilm, prevents infection, and reduces wound healing time, helping stalled wounds progress through normal healing phases. Copper, which is non-irritating and non-sensitizing, outperforms silver in all aspects. Current limitations are related to the available forms of copper dressings, but as new forms emerge, they will enhance wound management and patient recovery. Further research is needed to support these advancements.